Vitamin B12 is a water-soluble vitamin that is naturally present in some foods, added to others, and available as a dietary supplement and a prescription medication. Vitamin B12 exists in several forms and contains the mineral cobalt, so compounds with vitamin B12 activity are collectively called cobalamins. Methylcobalamin and 5-deoxyadenosylcobalamin are the forms of vitamin B12 that are active in human metabolism.

Vitamine B12 wordt ook wel cobalamine genoemd het bevat namelijk het metaal kobalt. B12 is een verzamelnaam voor een groep van kobalt bevattende verbindingen bekend als corrinoids. De belangrijkste cobalamine derivaten zijn cyano-cobalamine, hydroxocobalamine en de twee co-enzym vormen methyl-cobalamine en adenosyl-cobalamine.

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